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What You Should Know About XIGDUO XR


What You Should Know About XIGDUO XR

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When combined with diet and exercise, once-daily XIGDUO (zig-DOO-oh) XR provides a number of important benefits for adults with type 2 diabetes.

In a clinical trial, XIGDUO XR lowered A1C approximately 50% more than metformin alone.

Although XIGDUO XR is not a weight loss or blood pressure drug, XIGDUO XR additionally may help people lose weight—on average 3%—and lower their systolic blood pressure.§ Individual results may vary.

XIGDUO XR is a convenient, once-daily dose, taken in the morning with food.

XIGDUO XR combines two proven therapies, metformin and dapagliflozin, to help significantly lower blood sugar.

  • Metformin reduces the amount of sugar absorbed by the digestive system and made by the liver, and helps your body respond to its own insulin. Dapagliflozin removes some sugar through the urine

Do not take XIGDUO XR if you have moderate to severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with XIGDUO XR.

Understand the possible side effects

Serious side effects can happen in people who take XIGDUO XR, including:

  • Dehydration (the loss of body water and salt) which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure, take medicines to lower your blood pressure, including water pills (diuretics), are 65 years of age or older, are on a low-salt diet, or have kidney problems. Talk to your doctor about what you can do to prevent dehydration
  • Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with dapagliflozin, one of the medicines in XIGDUO XR. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking XIGDUO XR and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL
  • Kidney problems. Sudden kidney injury occurred in people taking XIGDUO XR. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure
  • Serious urinary tract infections (UTI), some that lead to hospitalization, occurred in people taking dapagliflozin, one of the medicines in XIGDUO XR. Tell your doctor if you have any signs or symptoms of UTI including a burning feeling when passing urine, a need to urinate often, the need to urinate right away, pain in the lower part of your stomach (pelvis), or blood in the urine with or without fever, back pain, nausea, or vomiting

If you experience any adverse reactions or discomfort while taking XIGDUO XR, talk to your doctor right away. The most common side effects of XIGDUO XR include yeast infections of the vagina or penis, stuffy or runny nose and sore throat, diarrhea, headache, nausea, and vomiting.

These are not all of the possible side effects of XIGDUO XR. Be sure to talk to your doctor for more information. See "What is the most important information I should know about XIGDUO XR?"

In a clinical study assessing dapagliflozin 5 mg + metformin XR.

Secondary end point.

§Other end point.


Check out an offer for most patients to get XIGDUO XR for a $0* co-pay
*Eligible commercially insured patients can get XIGDUO XR for as low as $0 as long as their doctor prescribes it. Subject to eligibility and monthly savings limit. Restrictions apply. Not available for government-insured patients.